Mathematics – Probability
Scientific paper
2007-09-18
Mathematics
Probability
Scientific paper
The evolutionary force of recombination is lacking in asexually reproducing populations. As a consequence, the population can suffer an irreversible accumulation of deleterious mutations, a phenomenon known as Muller's ratchet. We formulate discrete and continuous time versions of Muller's ratchet. Inspired by Haigh's (1978) analysis of a dynamical system which arises in the limit of large populations, we identify the parameter gamma = N*lambda/(Ns*log(N*lambda)) as most important for the speed of accumulation of deleterious mutations. Here N is population size, s is the selection coefficient and lambda is the deleterious mutation rate. For large parts of the parameter range, measuring time in units of size N, deleterious mutations accumulate according to a power law in N*lambda with exponent gamma if gamma>0.5. For gamma<0.5 mutations cannot accumulate. We obtain diffusion approximations for three different parameter regimes, depending on the speed of the ratchet. Our approximations shed new light on analyses of Stephan et al. (1993) and Gordo & Charlesworth (2000). The heuristics leading to the approximations are supported by simulations.
Etheridge Alison
Pfaffelhuber Peter
Wakolbinger Anton
No associations
LandOfFree
How often does the ratchet click? Facts, heuristics, asymptotics does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with How often does the ratchet click? Facts, heuristics, asymptotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and How often does the ratchet click? Facts, heuristics, asymptotics will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-456611