How Noise and Coupling Induce Bursting Action Potentials in Pancreatic beta-cells

Details How Noise and Coupling Induce Bursting Action Potentials in Pancreatic beta-cells How Noise and Coupling Induce Bursting Action Potentials in Pancreatic beta-cells

2005-09-05

arxiv.org/abs/q-bio/0509004v1

published in Biophysical Journal 89:1534-1542 (2005)

Biology

Quantitative Biology

Cell Behavior

40 pages, 10 figures

Scientific paper

10.1529/biophysj.104.053181

Unlike isolated beta-cells, which usually produce continuous spikes or fast and irregular bursts, electrically coupled beta-cells are apt to exhibit robust bursting action potentials. We consider the noise induced by thermal fluctuations as well as that by channel gating stochasticity and examine its effects on the action potential behavior of the beta-cell model. It is observed numerically that such noise in general helps single cells to produce a variety of electrical activities. In addition, we also probe coupling via gap junctions between neighboring cells,with heterogeneity induced by noise, to find that it enhances regular bursts.

Affiliated with

Also associated with

No associations

Rating

How Noise and Coupling Induce Bursting Action Potentials in Pancreatic beta-cells does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with How Noise and Coupling Induce Bursting Action Potentials in Pancreatic beta-cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and How Noise and Coupling Induce Bursting Action Potentials in Pancreatic beta-cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-378514