Biology – Quantitative Biology – Quantitative Methods
Scientific paper
2012-02-10
Phys. Chem. Chem. Phys., 2012, 14, 2301-2311
Biology
Quantitative Biology
Quantitative Methods
18 pages, 12 figures, 9 tables
Scientific paper
10.1039/c2cp22813k
We present a differential rate equation model of chiral polymerization based on a simple copolymerization scheme in which the enantiomers are added to, or removed from, the homochiral or heterochiral chains (reversible stepwise isodesmic growth or dissociation). The model is set up for closed systems and takes into account the corresponding thermodynamic constraints implied by the reversible monomer attachments, while obeying a constant mass constraint. In its simplest form, the model depends on a single variable rate constant, the maximum chain length N, and the initial concentrations. We have fit the model to the experimental data from the Rehovot group on lattice-controlled chiral amplification of oligopeptides. We find in all the chemical systems employed except for one, that the model fits the measured relative abundances of the oligopetides with higher degrees of correlation than from a purely random polymerization process.
Blanco Celia
Hochberg David
No associations
LandOfFree
Homochiral oligopeptides by chiral amplification: Interpretation of experimental data with a copolymerization model does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Homochiral oligopeptides by chiral amplification: Interpretation of experimental data with a copolymerization model, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Homochiral oligopeptides by chiral amplification: Interpretation of experimental data with a copolymerization model will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-275872