Biology – Quantitative Biology – Populations and Evolution
Scientific paper
2011-12-29
Biology
Quantitative Biology
Populations and Evolution
43 pages, 9 figures, 9 tables
Scientific paper
This article shows how to fit reticulate finite and infinite sites sequence spectra to aligned data from five modern human genomes (San, Yoruba, French, Han and Papuan) plus two archaic humans (Denisovan and Neanderthal), to better infer demographic parameters. These include interbreeding between distinct lineages. Major improvements in the fit of the sequence spectrum are made with successively more complicated models. Findings include some evidence of a male biased gene flow from the Denisova lineage to Papuan ancestors and possibly even more archaic gene flow. It is unclear if there is evidence for more than one Neanderthal interbreeding, as the evidence suggesting this largely disappears when a finite sites model is fitted.
Ramos Jorge
Tan Xi
Waddell Peter J.
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