Biology – Quantitative Biology – Tissues and Organs
Scientific paper
2009-02-10
HFSP J. 3 (4), 265-272 (2009)
Biology
Quantitative Biology
Tissues and Organs
13 pages, 11 figures, to be published in the HFSP Journal
Scientific paper
10.2976/1.3086732
We propose a mechanism for tumor growth emphasizing the role of homeostatic regulation and tissue stability. We show that competition between surface and bulk effects leads to the existence of a critical size that must be overcome by metastases to reach macroscopic sizes. This property can qualitatively explain the observed size distributions of metastases, while size-independent growth rates cannot account for clinical and experimental data. In addition, it potentially explains the observed preferential growth of metastases on tissue surfaces and membranes such as the pleural and peritoneal layers, suggests a mechanism underlying the seed and soil hypothesis introduced by Stephen Paget in 1889 and yields realistic values for metastatic inefficiency. We propose a number of key experiments to test these concepts. The homeostatic pressure as introduced in this work could constitute a quantitative, experimentally accessible measure for the metastatic potential of early malignant growths.
Basan Markus
Joanny Jean-Francois
Prost Jacques
Risler Thomas
Sastre-Garau Xavier
No associations
LandOfFree
Homeostatic competition drives tumor growth and metastasis nucleation does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Homeostatic competition drives tumor growth and metastasis nucleation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Homeostatic competition drives tumor growth and metastasis nucleation will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-20607