Global dynamics of cell mediated immunity in viral infection models with distributed delays

Details Global dynamics of cell mediated immunity in viral infection models with distributed delays Global dynamics of cell mediated immunity in viral infection models with distributed delays

2010-08-15

arxiv.org/abs/1008.2518v1

Mathematics

Dynamical Systems

16 pages, accepted by Journal of Mathematical Analysis and Applications

Scientific paper

In this paper, we investigate global dynamics for a system of delay differential equations which describes a virus-immune interaction in \textit{vivo}. The model has two distributed time delays describing time needed for infection of cell and virus replication. Our model admits three possible equilibria, an uninfected equilibrium and infected equilibrium with or without immune response depending on the basic reproduction number for viral infection $R_{0}$ and for CTL response $R_{1}$ such that $R_{1}1$. The immune activation has a positive role in the reduction of the infection cells and the increasing of the uninfected cells if $R_{1}>1$.

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