Biology – Quantitative Biology – Populations and Evolution
Scientific paper
2005-08-17
Biology
Quantitative Biology
Populations and Evolution
5 pages, 3 figures, to appear in Phys. Rev. Lett
Scientific paper
10.1103/PhysRevLett.95.148104
The immune system normally protects the human host against death by infection. However, when an immune response is mistakenly directed at self antigens, autoimmune disease can occur. We describe a model of protein evolution to simulate the dynamics of the adaptive immune response to antigens. Computer simulations of the dynamics of antibody evolution show that different evolutionary mechanisms, namely gene segment swapping and point mutation, lead to different evolved antibody binding affinities. Although a combination of gene segment swapping and point mutation can yield a greater affinity to a specific antigen than point mutation alone, the antibodies so evolved are highly cross-reactive and would cause autoimmune disease, and this is not the chosen dynamics of the immune system. We suggest that in the immune system a balance has evolved between binding affinity and specificity in the mechanism for searching the amino acid sequence space of antibodies.
Deem Michael W.
Earl David J.
Sun Jun
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