Biology – Quantitative Biology – Genomics
Scientific paper
Nov 2000
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2000amsci..88..508h&link_type=abstract
American Scientist, vol. 88, Issue 6, p.508
Biology
Quantitative Biology
Genomics
Scientific paper
These past few years of scientific discovery will undoubtedly be remembered as the "genomics era," the period in which biologists succeeded in enumerating the sequence of nucleotides making up all, or at least most, of human DNA. And while this achievement has been heralded as a technological feat equal to the moon landing, it is only the first of many advances in DNA technology. Scientists are now faced with the task of understanding the meaning of the DNA sequence. Specifically, they want to learn how the DNA code relates to protein function. An important tool in the study of "functional genomics," is the cDNA microarray—also known as the gene chip. Inspired by computer microchips, gene chips allow scientists to monitor the expression of hundreds, even thousands, of genes in a fraction of the time it used to take to monitor the expression of a single one. By altering the conditions under which a particular tissue expresses genes—say, by exposing it to toxins or growth factors—scientists can determine the suite of genes expressed in different situations and hence start to get a handle on the function of these genes. The authors discuss this important new technology and some of its practical applications.
Afshari Cynthia
Hamadeh Hisham
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