Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs

Details Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs Fundamentally different strategies for transcriptional regulation are revealed by information-theoretical analysis of binding motifs

2008-12-19

arxiv.org/abs/0812.3910v3

Biology

Quantitative Biology

Genomics

4 pages, 2 figures, expanded Supplementary Methods, Figures and Tables

Scientific paper

To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6-10^9 decoy sites? Our analysis of 319 known TF binding motifs clearly demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genome locations; eukaryotic TFs exhibit widespread nonfunctional binding and require clustering of sites in regulatory regions for specificity.

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