Biology – Quantitative Biology – Genomics
Scientific paper
2004-02-03
Biology
Quantitative Biology
Genomics
17 pages, 6 figures, 2 tables. accepted to PLOS Biology, Feb. 2004 issue
Scientific paper
The neutral mutation rate is known to vary widely along human chromosomes, leading to mutational hot and cold regions. We provide evidence that categories of functionally-related genes reside preferentially in mutationally hot or cold regions, the size of which we have measured. Genes in hot regions are biased toward extra-cellular communication (surface receptors, cell adhesion, immune response, etc.) while those in cold regions are biased toward essential cellular processes (gene regulation, RNA processing, protein modification, etc.). From a selective perspective, this organization of genes could minimize the mutational load on genes that need to be conserved and allow fast evolution for genes that must frequently adapt. We also analyze the effect of gene duplication and chromosomal recombination, which contribute significantly to these biases for certain categories of hot genes. Overall, our results show that genes are located non-randomly with respect to hot and cold regions, offering the possibility that selection acts at the level of gene location in the human genome.
Chuang Jeffrey H.
Li Hao
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