From systems biology to dynamical neuropharmacology: proposal for a new methodology

Details From systems biology to dynamical neuropharmacology: proposal for a new methodology From systems biology to dynamical neuropharmacology: proposal for a new methodology

2006-07-20

arxiv.org/abs/q-bio/0607031v1

Biology

Quantitative Biology

Neurons and Cognition

For an opinion paper see: Aradi and Erdi: Computational neuropharmacology: dynamical approaches in drug discovery TRENDS in

Scientific paper

The concepts and methods of Systems Biology are being extended to neuropharmacology, to test and design drugs against neurological and psychiatric disorders. Computational modeling by integrating compartmental neural modeling technique and detailed kinetic description of pharmacological modulation of transmitter-receptor interaction is offered as a method to test the electrophysiological and behavioral effects of putative drugs. Even more, an inverse method is suggested as a method for controlling a neural system to realize a prescribed temporal pattern. In particular, as an application of the proposed new methodology a computational platform is offered to analyze the generation and pharmacological modulation of theta rhythm related to anxiety is analyzed here in more detail.

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