From cellular properties to population asymptotics in the Population Balance Equation

Details From cellular properties to population asymptotics in the Population Balance Equation From cellular properties to population asymptotics in the Population Balance Equation

2008-04-30

arxiv.org/abs/0804.4804v3

PRL 101, 018104 (2008)

Biology

Quantitative Biology

Populations and Evolution

Exact solution of Eq. 9 is added

Scientific paper

10.1103/PhysRevLett.101.018104

Proliferating cell populations at steady state growth often exhibit broad protein distributions with exponential tails. The sources of this variation and its universality are of much theoretical interest. Here we address the problem by asymptotic analysis of the Population Balance Equation. We show that the steady state distribution tail is determined by a combination of protein production and cell division and is insensitive to other model details. Under general conditions this tail is exponential with a dependence on parameters consistent with experiment. We discuss the conditions for this effect to be dominant over other sources of variation and the relation to experiments.

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