Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences

Details Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences

2006-07-25

arxiv.org/abs/q-bio/0607046v1

PNAS 103, 11527- 11532 (2006); Aug 1, 2006 no 31

Biology

Quantitative Biology

Quantitative Methods

31 pages, 5 figures

Scientific paper

10.1073/pnas.0604316103

Major advances in large-scale yeast two hybrid (Y2H) screening have provided a global view of binary protein-protein interactions across species as dissimilar as human, yeast, and bacteria. Remarkably, these analyses have revealed that all species studied have a degree distribution of protein-protein binding that is approximately scale-free (varies as a power law) even though their evolutionary divergence times differ by billions of years. The universal power-law shows only the surface of the rich information harbored by these high-throughput data. We develop a detailed mathematical model of the protein-protein interaction network based on association free energy, the biochemical quantity that determines protein-protein interaction strength. This model reproduces the degree distribution of all of the large-scale Y2H data sets available and allows us to extract the distribution of free energy, the likelihood that a pair of proteins of a given species will bind. We find that across-species interactomes have significant differences that reflect the strengths of the protein-protein interaction. Our results identify a global evolutionary shift: more evolved organisms have weaker binary protein-protein binding. This result is consistent with the evolution of increased protein unfoldedness and challenges the dogma that only specific protein-protein interactions can be biologically functional..

Affiliated with

Also associated with

No associations

Rating

Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-665758