Formation of Glycolaldehyde Phosphate from Glycolaldehyde in Aqueous Solution

Details Formation of Glycolaldehyde Phosphate from Glycolaldehyde in Aqueous Solution Formation of Glycolaldehyde Phosphate from Glycolaldehyde in Aqueous Solution

Aug 1999

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1999oleb...29..333k&link_type=abstract

Origins of Life and Evolution of the Biosphere, v. 29, Issue 4, p. 333-354 (1999).

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Amidotriphosphate (0.1 M) in aqueous solution at near neutral pH in the presence of magnesium ions (0.25 M) converts glycolaldehyde (0.025 M) within days at room temperature into glycolaldehyde phosphate in (analytically) nearly quantitative yields (76% in isolated product). This robust phosphorylation process was observed to proceed at concentrations as low as 30 μM glycolaldehyde and 60 μM phosphorylation reagent under otherwise identical conditions. In sharp contrast, attempts to achieve a phosphorylation of glycolaldehyde with cyclotriphosphate (`trimetaphosphate') as phosphorylating reagent were unsuccessful. Mechanistically, the phosphorylation of glycolaldehyde with amidotriphosphate is an example of intramolecular delivery of the phosphate group.

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