Computer Science – Sound
Scientific paper
Aug 1994
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1994adspr..14..111c&link_type=abstract
Advances in Space Research, Volume 14, Issue 8, p. 111-114.
Computer Science
Sound
Scientific paper
Shuttle flight, sounding rocket flight, and parabolic flight experiments demonstrate the formation of bilayer membrane vesicles (liposomes) in reduced gravity, following the dilution of detergent from detergent-phospholipid mixed micelles. The reduction in detergent concentration initiates assembly of bilayer membrane sheets, which are sensitive to solution distrubances. An increase in distrubances by forced dilution results in small diameter liposomes (< 150 nm), in both ground and flight samples. In the absence of forced dilution, liposomes remain small at 1-g, but exhibit much larger diameters at 0-g (1000-2000 nm). Our spaceflight data reveal that membrane assembly and vesiculation are strongly influenced by gravity-induced solution disturbances (e.g., convection currents), which limit vesicle diameter.
Claasen Dale E.
Spooner Brian S.
van Twest Jacqueline S.
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