Formation and Stability of Synaptic Receptor Domains

Details Formation and Stability of Synaptic Receptor Domains Formation and Stability of Synaptic Receptor Domains

2010-12-20

arxiv.org/abs/1012.4422v1

Phys. Rev. Lett. 106, 238104 (2011)

Biology

Quantitative Biology

Neurons and Cognition

5 pages, 3 figures, Supplementary Material

Scientific paper

Neurotransmitter receptor molecules, concentrated in postsynaptic domains along with scaffold and a number of other molecules, are key regulators of signal transmission across synapses. Employing experiment and theory, we develop a quantitative description of synaptic receptor domains in terms of a reaction-diffusion model. We show that interactions between only receptor and scaffold molecules, together with the rapid diffusion of receptors on the cell membrane, are sufficient for the formation and stable characteristic size of synaptic receptor domains. Our work reconciles long-term stability of synaptic receptor domains with rapid turnover and diffusion of individual receptors.

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