Fluid and Electrolyte Balance and Kidney Function Research in Space

Details Fluid and Electrolyte Balance and Kidney Function Research in Space Fluid and Electrolyte Balance and Kidney Function Research in Space

Jun 2005

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2005esasp1281..120n&link_type=abstract

In: Topical Teams in Life & Physical Sciences: Towards new research applications. Edited by Andrew Wilson, coordination: Benny E

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Fluid and electrolyte regulation in humans is modulated by gravitational stress through a complex interaction of cardiovascular reflexes, neuroendocrine variables, physical factors and renal function.Weightlessness is a unique tool to obtain more information on integrated fluid volume control. Results from space, however, have been unexpected and unpredictable from the results of ground- based simulations.The concept of how weightlesness and gravity modulate the regulation of body fluids and associated blood components must therefore be revised and a new simulation model developed. There are several main questions to be asked. Does weightlessness induce diuresis and natriuresis during the initial hours of spaceflight, leading to an extracellular and intravascular fluid volume deficit? Why are fluid- and sodium-retaining systems activated by spaceflight, and why are the renal responses to saline and water stimuli attenuated? Can excess sodium be stored in an hitherto unknown way, in particular during spaceflight? How can the effects of weightlessness on fluid and electrolyte regulation be correctly simulated on the ground? The information obtained from space might help us to understand how gravity degrades the fluid and electrolyte balance in sodium-retaining and oedema- forming states, such as in heart failure.

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