Biology – Quantitative Biology – Subcellular Processes
Scientific paper
2008-01-09
Biology
Quantitative Biology
Subcellular Processes
Scientific paper
10.1103/PhysRevLett.101.128103
Mechanochemical coupling was studied for two different types of myosin motors in cells: myosin V, which carries cargo over long distances by as a single molecule; and myosin II, which generates a contracting force in cooperation with other myosin II molecules. Both mean and variance of myosin V velocity at various [ATP] obeyed Michaelis-Menten mechanics, consistent with tight mechanochemical coupling. Myosin II, working in an ensemble, however, was explained by a loose coupling mechanism, generating variable step sizes depending on the ATP concentration and realizing a much larger step (200 nm) per ATP hydrolysis than myosin V through its cooperative nature at zero load. These different mechanics are ideal for the respective myosin's physiological functions.
Iwane Atsuko H.
Nishikawa Masatoshi
Takagi Hiroaki
Yanagida Toshio
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