Fish as osteoporosis research models

Details Fish as osteoporosis research models Fish as osteoporosis research models

Oct 2005

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2005esasp1290..316g&link_type=abstract

In: Microgravity applications programme: Successful teaming of science and industry. Edited by Andrew Wilson, coordination: Benn

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Life Sciences, Bone Structure

Scientific paper

Osteoporosis, characterised by a progressive loss of bone density, is one of the most important bone diseases of humans worldwide. During spaceflight, astronauts also suffer bone loss that strongly resembles osteoporosis in patients on Earth. In addition to these human disorders, skeletal malformations often cause problems in industrial animal production. Although the alterations of bone homeostasis that lead to osteoporosis are well-documented at the cellular level, the molecular events underlying this disease are still poorly understood. Moreover, most of our knowledge is derived from in vitro studies using cell culture systems. Recent findings indicate a remarkable conservation of key regulators of bone development and bone homeostasis between fish and mammals, both at the sequence and expression levels.

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