Biology – Quantitative Biology – Cell Behavior
Scientific paper
2012-01-05
Journal of Computing, Volume 3, Issue 11, 2011, 74-80
Biology
Quantitative Biology
Cell Behavior
7 pages, 9 figures, journal; ISSN 2151-9617 https://sites.google.com/site/journalofcomputing; http://www.journalofcomputing.
Scientific paper
Most of the intra-cellular events involved in the initiation and propagation phases of this process has now been identified astrocytes. The control of the spread of intracellular calcium signaling has been demonstrated to occur at several levels including IP3 receptors, intracellular Ca2+ stores like endoplasmic reticulum (ER) . In normal and pathological situations that affect one or several of these steps can be predicted to influence on astrocytic calcium waves. In view of above a mathematical model is developed to study interdependence of all the important parameters like diffusion coefficient and influx over [Ca2+] profile. Model incorporates the ER fluxes like, leak Pump Chan J J andJ . Finite volume method is employed to solve the problem. A program has been developed using in MATLAB 7.5 for the entire problem and simulated on an AMD-Turion 32-bite machine to compute the numerical results. In view of above a mathematical model is developed to study calcium transport between cytosol and ER.
Adlakha Neeru
Jha Brajesh Kumar
Mehta M. N.
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