Extracting synaptic conductances from single membrane potential traces

Details Extracting synaptic conductances from single membrane potential traces Extracting synaptic conductances from single membrane potential traces

2008-07-21

arxiv.org/abs/0807.3238v2

Neuroscience 158: 545-552, 2009.

Biology

Quantitative Biology

Neurons and Cognition

Neuroscience (in press)

Scientific paper

10.1016/j.neuroscience.2008.10.0

In awake animals, the activity of the cerebral cortex is highly complex, with neurons firing irregularly with apparent Poisson statistics. One way to characterize this complexity is to take advantage of the high interconnectivity of cerebral cortex and use intracellular recordings of cortical neurons, which contain information about the activity of thousands of other cortical neurons. Identifying the membrane potential (Vm) to a stochastic process enables the extraction of important statistical signatures of this complex synaptic activity. Typically, one estimates the total synaptic conductances (excitatory and inhibitory) but this type of estimation requires at least two Vm levels and therefore cannot be applied to single Vm traces. We propose here a method to extract excitatory and inhibitory conductances (mean and variance) from single Vm traces. This "VmT method" estimates conductance parameters using maximum likelihood criteria, under the assumption are that synaptic conductances are described by Gaussian stochastic processes and are integrated by a passive leaky membrane. The method is illustrated using models and is tested on guinea-pig visual cortex neurons in vitro using dynamic-clamp experiments. The VmT method holds promises for extracting conductances from single-trial measurements, which has a high potential for in vivo applications.

Affiliated with

Also associated with

No associations

Rating

Extracting synaptic conductances from single membrane potential traces does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Extracting synaptic conductances from single membrane potential traces, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Extracting synaptic conductances from single membrane potential traces will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-71845