Biology – Quantitative Biology – Quantitative Methods
Scientific paper
2004-06-06
Evolution as Computation, Springer Natural Computing Series, Landweber and Winfree eds., 2002, pp. 41-66
Biology
Quantitative Biology
Quantitative Methods
26 pages, 8 figures, presented at the DIMACS Workshop on Evolution as Computation, 1998
Scientific paper
We study the maturation of the antibody population following primary antigen presentation as a global optimization problem. Emphasis is placed on the trade-off between the safety of mutations that lead to local improvements to the antibody's affinity and the necessity of eventual mutations that result in global reconfigurations in the antibody's shape. The model described herein gives evidence of the underlying optimization process from which the rapidity and consistency of the biologic response could be derived.
Theodosopoulos Patricia
Theodosopoulos Ted
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