Epistasis and Shapes of Fitness Landscapes

Details Epistasis and Shapes of Fitness Landscapes Epistasis and Shapes of Fitness Landscapes

2006-03-29

arxiv.org/abs/q-bio/0603034v2

Biology

Quantitative Biology

Populations and Evolution

31 pages, 7 figures; typos removed, Example 3.10 added

Scientific paper

The relationship between the shape of a fitness landscape and the underlying gene interactions, or epistasis, has been extensively studied in the two-locus case. Gene interactions among multiple loci are usually reduced to two-way interactions. We present a geometric theory of shapes of fitness landscapes for multiple loci. A central concept is the genotope, which is the convex hull of all possible allele frequencies in populations. Triangulations of the genotope correspond to different shapes of fitness landscapes and reveal all the gene interactions. The theory is applied to fitness data from HIV and Drosophila melanogaster. In both cases, our findings refine earlier analyses and reveal previously undetected gene interactions.

Affiliated with

Also associated with

No associations

Rating

Epistasis and Shapes of Fitness Landscapes does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Epistasis and Shapes of Fitness Landscapes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epistasis and Shapes of Fitness Landscapes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-586444