Emergence of Template-and-Sequence-Directed (TSD) Syntheses: I. A Bio-Geochemical Model

Details Emergence of Template-and-Sequence-Directed (TSD) Syntheses: I. A Bio-Geochemical Model Emergence of Template-and-Sequence-Directed (TSD) Syntheses: I. A Bio-Geochemical Model

Aug 1997

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1997oleb...27..377l&link_type=abstract

Origins of Life and Evolution of the Biosphere, v. 27, Issue 4, p. 377-395 (1997).

Mathematics

Logic

6

Scientific paper

A biogeochemical model for the evolution of template-and-sequence-directed (TSD) syntheses of biological templates (proto-RNAs) and catalysts (peptides) is described. A fluctuating environment characterized by hydrating (cool) and dehydrating (warm) phases with cycles of consecutive organic reactions, as well as a constant supply of the polymeric building blocks is assumed. The scenario starts with the catalyzed formation of a primordial population of small random peptides, based on the relatively-ineffective mineral catalysts. The resulting peptides initiate a catalytic takeover process, during which the catalytic functions are gradually taken over by peptides. The evolution of TSD peptides is based on a combination of Lahav's (1991) co-evolution and Möller and Janssen's (1990) specific recognition sites hypotheses. During the emergence of TSD systems the fraction of TSD peptides and proto-RNA constituents rises from almost insignificance to dominance in a TSD Reactions Takeover. The TSD system is characterized by autocatalysis, positive feedback loops and a primordial genetic code. The model is the basis for a computer program (Part II of present series).

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