Effects of multiple occupancy and inter-particle interactions on selective transport through narrow channels: theory versus experiment

Details Effects of multiple occupancy and inter-particle interactions on selective transport through narrow channels: theory versus experiment Effects of multiple occupancy and inter-particle interactions on selective transport through narrow channels: theory versus experiment

2008-11-17

arxiv.org/abs/0811.2791v1

Biology

Quantitative Biology

Subcellular Processes

27 pages, 6 figures, 1 Appendix, in press in Biophysical Journal

Scientific paper

10.1016/j.bpj.2008.09.058

Many biological and artificial transport channels function without direct input of metabolic energy during a transport event and without structural rearrangements involving transitions from a 'closed' to an 'open' state. Nevertheless, such channels are able to maintain efficient and selective transport. It has been proposed that attractive interactions between the transported molecules and the channel can increase the transport efficiency and that the selectivity of such channels can be based on the strength of the interaction of the specifically transported molecules with the channel. Herein, we study the transport through narrow channels in a framework of a general kinetic theory, which naturally incorporates multi-particle occupancy of the channel and non-single-file transport. We study how the transport efficiency and the probability of translocation through the channel are affected by inter-particle interactions in the confined space inside the channel, and establish conditions for selective transport. We compare the predictions of the model with the available experimental data - and find good semi-quantitative agreement. Finally, we discuss applications of the theory to the design of artificial nano-molecular sieves.

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