Effects of a synchronizer phase-shift on circadian rhythms in response of mice to ethanol or ouabain

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Scientific paper

The percentage of mice dying from a toxic dose of ethanol or ouabain was determined at 4-hour intervals during the first 3 days after inversion of an LD(12:12) lighting regimen. In comparison to unshifted control animals at similar stages of the synchronizer schedule, spans of relative advantage alternated with spans of relative disadvantage due to a gradual phase-shift of the circadian susceptibility rhythm. Overall mortality, determined for an integral number of day, was not obviously affected by the regimen-shift.

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