Early Chemical Evolution of Nucleic Acids: A Theoretical Model

Details Early Chemical Evolution of Nucleic Acids: A Theoretical Model Early Chemical Evolution of Nucleic Acids: A Theoretical Model

Apr 1977

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1977sci...196..311u&link_type=abstract

Science, Volume 196, Issue 4287, pp. 311-313

Computer Science

12

Scientific paper

Recent experimental work suggests a possible cyclical pathway for early prebiotic oligonucleotide formation that involves (i) dry-state (nontemplate) synthesis of random copolymers with mixed 2',5' and 3',5' bonds, (ii) passage of these oligomers into solution at low temperatures, and (iii) a preferential hydrolysis of the 2',5' bond in any short helices that have formed. This early system could have selected for complementary sequences that were largely 3',5'-linked, but may not have selected efficiently for a single enantiomer of ribose.

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