Dynamics of Acute Inflammation

Details Dynamics of Acute Inflammation Dynamics of Acute Inflammation

2004-04-23

arxiv.org/abs/q-bio/0404034v1

Biology

Quantitative Biology

Tissues and Organs

27 pages, 9 figures, Accepted by the Journal of Theoretical Biology

Scientific paper

When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as Sepsis and can culminate in organ failure and death. We consider a three dimensional ordinary differential equation model of inflammation consisting of a pathogen, and two inflammatory mediators. The model reproduces the healthy outcome and diverse negative outcomes, depending on initial conditions and parameters.when key parameters are changed and suggest various therapeutic strategies. We suggest that the clinical condition of sepsis can arise from several distinct physiological states, each of which requires a different treatment approach. We analyze the various bifurcations between the different outcomes

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