Statistics – Applications
Scientific paper
Jan 1997
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1997aipc..387..697g&link_type=abstract
Space technology and applications international forum (STAIF - 97). AIP Conference Proceedings, Volume 387, pp. 697-704 (1997).
Statistics
Applications
Dynamics And Conformational Changes, Exafs Spectroscopy
Scientific paper
This laboratory has designed a protein crystallization system which controls the supersaturation state of proteins via precise temperature changes. The system is coupled to lasers to monitor the aggregation state of the protein and to provide a mechanism for dynamic control of the crystallization process (DC/PCGT). This automated dynamic control process has resulted in systematic and predictable responses with regard to crystal size. However, in order to successfully use temperature-induced crystallization, it is necessary to understand, at least qualitatively, the dependence of protein solubility on temperature. These data are available for a limited number of proteins. We have therefore designed a multichambered thermal gradient device. This device uses microliter amounts of protein solutions and has been instrumental, not only as a means of screening protein solubility as a function of temperature, but in optimizing crystallizing conditions.
Arabshahi Ali
Delucas Lawrence J.
Gray Richard J.
Kim Larry J.
Wilson William W.
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