Drug absorption through a cell monolayer: a theoretical work on a non-linear three-compartment model

Details Drug absorption through a cell monolayer: a theoretical work on a non-linear three-compartment model Drug absorption through a cell monolayer: a theoretical work on a non-linear three-compartment model

2008-05-26

arxiv.org/abs/0805.3757v4

European Journal of Pharmaceutical Sciences, 37 (2009), 106-114

Biology

Quantitative Biology

Other Quantitative Biology

21 pages, 8 figures (v4: detailed definition of the treated model - additional information about limitations)

Scientific paper

10.1016/j.ejps.2009.01.005

The subject of analysis is a non-linear three-compartment model, widely used in pharmacological absorption studies. It has been transformed into a general form, thus leading automatically to an appropriate approximation. This made the absorption profile accessible and expressions for absorption times, apparent permeabilities and equilibrium values were given. These findings allowed a profound analysis of results from non-linear curve fits and delivered the dependencies on the systems' parameters over a wide range of values. The results were applied to an absorption experiment with multidrug transporter-affected antibiotic CNV97100 on Caco-2 cell monolayers.

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