Domain Evolution and Functional Diversification of Sulfite Reductases

Details Domain Evolution and Functional Diversification of Sulfite Reductases Domain Evolution and Functional Diversification of Sulfite Reductases

Feb 2005

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2005asbio...5...18d&link_type=abstract

Astrobiology, Volume 5, Issue 1, pp. 18-29.

Biology

1

Dissimilatory Sulfite Reductase, Anaerobic Sulfite Reductase, Assimilatory Sulfite Reductase, Low-Molecular-Weight Assimilatory Sulfite Reductase

Scientific paper

Sulfite reductases are key enzymes of assimilatory and dissimilatory sulfur metabolism, which occur in diverse bacterial and archaeal lineages. They share a highly conserved domain "C-X5-C-n-C-X3-C" for binding siroheme and iron-sulfur clusters that facilitate electron transfer to the substrate. For each sulfite reductase cluster, the siroheme-binding domain is positioned slightly differently at the N-terminus of dsrA and dsrB, while in the assimilatory proteins the siroheme domain is located at the C-terminus. Our sequence and phylogenetic analysis of the siroheme-binding domain shows that sulfite reductase sequences diverged from a common ancestor into four separate clusters (aSir, alSir, dsr, and asrC) that are biochemically distinct; each serves a different assimilatory or dissimilatory role in sulfur metabolism. The phylogenetic distribution and functional grouping in sulfite reductase clusters (dsrA and dsrB vs. aSiR, asrC, and alSir) suggest that their functional diversification during evolution may have preceded the bacterial/archaeal divergence.

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