Mathematics – Logic
Scientific paper
Jan 2004
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2004adspr..34.1353a&link_type=abstract
Advances in Space Research, Volume 34, Issue 6, p. 1353-1357.
Mathematics
Logic
2
Radiation Risk, Dna Fragmentation, Fe Ions In Human Cells, Radiation Shielding, Radiation Dose
Scientific paper
Outside the magnetic field of the Earth, high energy heavy ions constitute a relevant part of the biologically significant dose to astronauts during the very long travels through space. The typical pattern of energy deposition in the matter by heavy ions on the microscopic scale is believed to produce spatially correlated damage in the DNA which is critical for radiobiological effects. We have investigated the influence of a lucite shielding on the initial production of very small DNA fragments in human fibroblasts irradiated with 1 GeV/u iron (Fe) ions. We also used γ-rays as reference radiation. Our results show: (1) a lower effect per incident ion when the shielding is used; (2) an higher DNA Double Strand Breaks (DSB) induction by Fe ions than by γ-rays in the size range 1-23 kbp; (3) a non-random DNA DSB induction by Fe ions.
Antonelli F.
Belli Matteo
Campa Alessandro
Chatterjee Arnab
Dini V.
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