Biology – Quantitative Biology – Neurons and Cognition
Scientific paper
2012-03-05
Biology
Quantitative Biology
Neurons and Cognition
11 pages, 7 figures; PloS One 2010
Scientific paper
10.1371/journal.pone.0009608
Extracellular recordings of single neurons in primary and secondary somatosensory cortices of monkeys in vivo have shown that their firing rate can increase, decrease, or remain constant in different cells, as the external stimulus frequency increases. We observed similar intrinsic firing patterns (increasing, decreasing or constant) in rat somatosensory cortex in vitro, when stimulated with oscillatory input using conductance injection (dynamic clamp). The underlying mechanism of this observation is not obvious, and presents a challenge for mathematical modelling. We propose a simple principle for describing this phenomenon using a leaky integrate-and-fire model with sinusoidal input, an intrinsic oscillation and Poisson noise. Additional enhancement of the gain of encoding could be achieved by local network connections amongst diverse intrinsic response patterns. Our work sheds light on the possible cellular and network mechanisms underlying these opposing neuronal responses, which serve to enhance signal detection.
Feng Jianfeng
Kang Jing
Robinson Hugh P. C.
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