Diverse correlation structures in gene expression data and their utility in improving statistical inference

Details Diverse correlation structures in gene expression data and their utility in improving statistical inference Diverse correlation structures in gene expression data and their utility in improving statistical inference

2007-12-13

arxiv.org/abs/0712.2130v1

Annals of Applied Statistics 2007, Vol. 1, No. 2, 538-559

Statistics

Applications

Published in at http://dx.doi.org/10.1214/07-AOAS120 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Ins

Scientific paper

10.1214/07-AOAS120

It is well known that correlations in microarray data represent a serious nuisance deteriorating the performance of gene selection procedures. This paper is intended to demonstrate that the correlation structure of microarray data provides a rich source of useful information. We discuss distinct correlation substructures revealed in microarray gene expression data by an appropriate ordering of genes. These substructures include stochastic proportionality of expression signals in a large percentage of all gene pairs, negative correlations hidden in ordered gene triples, and a long sequence of weakly dependent random variables associated with ordered pairs of genes. The reported striking regularities are of general biological interest and they also have far-reaching implications for theory and practice of statistical methods of microarray data analysis. We illustrate the latter point with a method for testing differential expression of nonoverlapping gene pairs. While designed for testing a different null hypothesis, this method provides an order of magnitude more accurate control of type 1 error rate compared to conventional methods of individual gene expression profiling. In addition, this method is robust to the technical noise. Quantitative inference of the correlation structure has the potential to extend the analysis of microarray data far beyond currently practiced methods.

Affiliated with

Also associated with

No associations

Rating

Diverse correlation structures in gene expression data and their utility in improving statistical inference does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Diverse correlation structures in gene expression data and their utility in improving statistical inference, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diverse correlation structures in gene expression data and their utility in improving statistical inference will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-622990