Distance based Inference for Gene-Ontology Analysis of Microarray Experiments

Details Distance based Inference for Gene-Ontology Analysis of Microarray Experiments Distance based Inference for Gene-Ontology Analysis of Microarray Experiments

2006-07-18

arxiv.org/abs/q-bio/0607026v1

Biology

Quantitative Biology

Genomics

Submitted to Journal of Statistical Planning and Inference

Scientific paper

The increasing availability of high throughput data arising from gene expression studies leads to the necessity of methods for summarizing the available information. As annotation quality improves it is becoming common to rely on the Gene Ontology (GO) to build functional profiles that characterize a set of genes using the frequency of use of each GO term or group of terms in the array. In this work we describe a statistical model for such profiles, provide methods to compare profiles and develop inferential procedures to assess this comparison. An R-package implementing the methods is available.

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