Destruction of CD4 T Lymphocytes Alone Cannot Account for their Long-term Decrease in AIDS

Details Destruction of CD4 T Lymphocytes Alone Cannot Account for their Long-term Decrease in AIDS Destruction of CD4 T Lymphocytes Alone Cannot Account for their Long-term Decrease in AIDS

2000-08-07

arxiv.org/abs/math/0008052v1

Mathematics

Dynamical Systems

5 pages 4 figures

Scientific paper

Following previous models describing a quasi steady state (QSS) for the evolution of HIV infection and AIDS, we have developed a larger formalism simulating the long-term evolution of the QSS We show that the long-term evolution of AIDS cannot be explained by the destruction alone of CD4 T cells, either directly or indirectly. The destruction of CD4 T cells can lead only to a QSS with a lower concentration of CD4 T cells, but CD4 destruction cannot generate the sustained long-term decrease in T cells leading to AIDS. We here suggest some workable explanations.

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