Mathematics – Statistics Theory
Scientific paper
2007-10-17
Annals of Statistics 2007, Vol. 35, No. 4, 1432-1455
Mathematics
Statistics Theory
Published in at http://dx.doi.org/10.1214/009053607000000046 the Annals of Statistics (http://www.imstat.org/aos/) by the Inst
Scientific paper
10.1214/009053607000000046
Some effort has been undertaken over the last decade to provide conditions for the control of the false discovery rate by the linear step-up procedure (LSU) for testing $n$ hypotheses when test statistics are dependent. In this paper we investigate the expected error rate (EER) and the false discovery rate (FDR) in some extreme parameter configurations when $n$ tends to infinity for test statistics being exchangeable under null hypotheses. All results are derived in terms of $p$-values. In a general setup we present a series of results concerning the interrelation of Simes' rejection curve and the (limiting) empirical distribution function of the $p$-values. Main objects under investigation are largest (limiting) crossing points between these functions, which play a key role in deriving explicit formulas for EER and FDR. As specific examples we investigate equi-correlated normal and $t$-variables in more detail and compute the limiting EER and FDR theoretically and numerically. A surprising limit behavior occurs if these models tend to independence.
Dickhaus Thorsten
Finner Helmut
Roters Markus
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