Biology – Quantitative Biology – Subcellular Processes
Scientific paper
2008-06-24
Biology
Quantitative Biology
Subcellular Processes
38 pages, 1 table, 12 figures. To be published in Journal of Chemical Physics
Scientific paper
10.1063/1.2958268
The plasma membrane of human red blood cells consists of a lipid bilayer attached to a regular network of underlying cytoskeletal polymers. We model this system at a dynamic coarse-grained level, treating the bilayer as an elastic sheet and the cytoskeletal network as a series of phantom entropic springs. In contrast to prior simulation efforts, we explicitly account for dynamics of the cytoskeletal network, both via motion of the protein anchors that attach the cytoskeleton to the bilayer and through breaking and reconnection of individual cytoskeletal filaments. Simulation results are explained in the context of a simple mean-field percolation model and comparison is made to experimental measurements of red blood cell fluctuation amplitudes.
Brown Frank L. H.
Zhang Rui
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