Converting genetic network oscillations into somite spatial pattern

Biology – Quantitative Biology – Quantitative Methods

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

7 pages, 7 figures

Scientific paper

10.1103/PhysRevE.78.021906

In most vertebrate species, the body axis is generated by the formation of repeated transient structures called somites. This spatial periodicity in somitogenesis has been related to the temporally sustained oscillations in certain mRNAs and their associated gene products in the cells forming the presomatic mesoderm. The mechanism underlying these oscillations have been identified as due to the delays involved in the synthesis of mRNA and translation into protein molecules [J. Lewis, Current Biol. {\bf 13}, 1398 (2003)]. In addition, in the zebrafish embryo intercellular Notch signalling couples these oscillators and a longitudinal positional information signal in the form of an Fgf8 gradient exists that could be used to transform these coupled temporal oscillations into the observed spatial periodicity of somites. Here we consider a simple model based on this known biology and study its consequences for somitogenesis. Comparison is made with the known properties of somite formation in the zebrafish embryo . We also study the effects of localized Fgf8 perturbations on somite patterning.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

Converting genetic network oscillations into somite spatial pattern does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Converting genetic network oscillations into somite spatial pattern, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Converting genetic network oscillations into somite spatial pattern will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-224891

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.