Continual Reassessment and Related Dose-Finding Designs

Details Continual Reassessment and Related Dose-Finding Designs Continual Reassessment and Related Dose-Finding Designs

2010-11-29

arxiv.org/abs/1011.6251v1

Statistical Science 2010, Vol. 25, No. 2, 202-216

Statistics

Methodology

Published in at http://dx.doi.org/10.1214/10-STS332 the Statistical Science (http://www.imstat.org/sts/) by the Institute of M

Scientific paper

10.1214/10-STS332

During the last twenty years there have been considerable methodological developments in the design and analysis of Phase 1, Phase 2 and Phase 1/2 dose-finding studies. Many of these developments are related to the continual reassessment method (CRM), first introduced by O'Quigley, Pepe and Fisher (\citeyearQPF1990). CRM models have proven themselves to be of practical use and, in this discussion, we investigate the basic approach, some connections to other methods, some generalizations, as well as further applications of the model. We obtain some new results which can provide guidance in practice.

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