Biology – Quantitative Biology – Neurons and Cognition
Scientific paper
2012-03-05
Biology
Quantitative Biology
Neurons and Cognition
16 pages
Scientific paper
Human brain contains about 10 billion neurons, each of which has about 10~10,000 nerve endings from which neurotransmitters are released in response to incoming spikes, and the released neurotransmitters then bind to receptors located in the postsynaptic neurons. However, individually, neurons are noisy and synaptic release is in general unreliable. But groups of neurons that are arranged in specialized modules can collectively perform complex information processing tasks robustly and reliably. How functionally groups of neurons perform behavioural related tasks crucial rely on a coherent organization of dynamics from membrane ionic kinetics to synaptic coupling of the network and dynamics of rhythmic oscillations that are tightly linked to behavioural state. To capture essential features of the biological system at multiple spatial-temporal scales, it is important to construct a suitable computational model that is closely or solely based on experimental data. Depending on what one wants to understand, these models can either be very functional and biologically realistic descriptions with thousands of coupled differential equations (Hodgkin-Huxley type) or greatly simplified caricatures (integrate-and-fire type) which are useful for studying large interconnected networks.
Feng Jianfeng
Zhang Xuejuan
No associations
LandOfFree
Computational modeling of neuronal networks does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Computational modeling of neuronal networks, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Computational modeling of neuronal networks will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-132774