Biology – Quantitative Biology – Genomics
Scientific paper
2008-09-08
Biology
Quantitative Biology
Genomics
Preliminary draft. Ongoing work to be submitted in refereed conferences and/or journals
Scientific paper
Copy Number Variations (CNVs) of regions of the human genome are important in disease association studies.The digital array is a nanofluidic biochip which utilizes integrated channels and valves that partition mixtures of sample and reagents into 765 nanovolume reaction chambers. It was recently shown how one can perform statistical analysis of CNV in a DNA sample the digital array. In particular, it was shown how one can accurately estimate the true concentration of the molecules in the DNA sample and then determine the ratios of different sequences along with statistical confidence intervals on these estimations. In this paper we perform computation of maximum number of copies which can be distinguished using the digital array which gives its resolution in terms of its ability to determine CNV. Then, we demonstrate the usefulness of the mathematical analysis to solve an important real-world problem of determination of the copy number of X chromosome as our example application.
Dube Simant
Jones Robert C.
Mir Alain
Ramakrishnan Ramesh
Sun Gang
No associations
LandOfFree
Computation of Maximal Resolution of Copy Number Variation on a Nanofluidic Device using Digital PCR does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Computation of Maximal Resolution of Copy Number Variation on a Nanofluidic Device using Digital PCR, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Computation of Maximal Resolution of Copy Number Variation on a Nanofluidic Device using Digital PCR will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-210228