Biology – Quantitative Biology – Neurons and Cognition
Scientific paper
2009-12-16
Biology
Quantitative Biology
Neurons and Cognition
Scientific paper
The stochastic opening and closing of voltage-gated ion channels produces noise in neurons. The effect of this noise on the neuronal performance has been modelled using either approximate or Langevin model, based on stochastic differential equations or an exact model, based on a Markov process model of channel gating. Yet whether the Langevin model accurately reproduces the channel noise produced by the Markov model remains unclear. Here we present a comparison between Langevin and Markov models of channel noise in neurons using single compartment Hodgkin-Huxley models containing either $Na^{+}$ and $K^{+}$, or only $K^{+}$ voltage-gated ion channels. The performance of the Langevin and Markov models was quantified over a range of stimulus statistics, membrane areas and channel numbers. We find that in comparison to the Markov model, the Langevin model underestimates the noise contributed by voltage-gated ion channels, overestimating information rates for both spiking and non-spiking membranes. Even with increasing numbers of channels the difference between the two models persists. This suggests that the Langevin model may not be suitable for accurately simulating channel noise in neurons, even in simulations with large numbers of ion channels.
Laughlin S. B.
Niven J. E.
Sengupta B.
No associations
LandOfFree
Comparison of Langevin and Markov channel noise models for neuronal signal generation does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Comparison of Langevin and Markov channel noise models for neuronal signal generation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Comparison of Langevin and Markov channel noise models for neuronal signal generation will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-684585