Biology – Quantitative Biology – Quantitative Methods
Scientific paper
2004-08-09
Eur. Phys. J. B 37, 109 115 (2004)
Biology
Quantitative Biology
Quantitative Methods
Scientific paper
10.1140/epjb/e2004-00035-y
The complexity of a neuronal cell shape is known to be related to its function. Specifically, among other indicators, a decreased complexity in the dendritic trees of cortical pyramidal neurons has been associated with mental retardation. In this paper we develop a procedure to address the characterization of morphological changes induced in cultured neurons by over-expressing a gene involved in mental retardation. Measures associated with the multiscale connectivity, an additive image functional, are found to give a reasonable separation criterion between two categories of cells. One category consists of a control group and two transfected groups of neurons, and the other, a class of cat ganglionary cells. The reported framework also identified a trend towards lower complexity in one of the transfected groups. Such results establish the suggested measures as an effective descriptors of cell shape.
Barbosa Marconi Soares
Bernardes Esmerindo S.
Costa Luciano da F.
Pelt van J.
Ramakers G.
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