Biology – Quantitative Biology – Genomics
Scientific paper
2010-06-16
PLoS ONE 5(6):e10907 2010
Biology
Quantitative Biology
Genomics
11 pages, 4 figures
Scientific paper
10.1371/journal.pone.0010907
Insertion of transposed elements within mammalian genes is thought to be an important contributor to mammalian evolution and speciation. Insertion of transposed elements into introns can lead to their activation as alternatively spliced cassette exons, an event called exonization. Elucidation of the evolutionary constraints that have shaped fixation of transposed elements within human and mouse protein coding genes and subsequent exonization is important for understanding of how the exonization process has affected transcriptome and proteome complexities. Here we show that exonization of transposed elements is biased towards the beginning of the coding sequence in both human and mouse genes. Analysis of single nucleotide polymorphisms (SNPs) revealed that exonization of transposed elements can be population-specific, implying that exonizations may enhance divergence and lead to speciation. SNP density analysis revealed differences between Alu and other transposed elements. Finally, we identified cases of primate-specific Alu elements that depend on RNA editing for their exonization. These results shed light on TE fixation and the exonization process within human and mouse genes.
Ast Gil
Hotz-Wagenblatt Agnes
Mersch Britta
Sela Noa
No associations
LandOfFree
Characteristics of transposable element exonization within human and mouse does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Characteristics of transposable element exonization within human and mouse, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Characteristics of transposable element exonization within human and mouse will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-100311