Catalytic Activities Of [GADV]-Peptides

Details Catalytic Activities Of [GADV]-Peptides Catalytic Activities Of [GADV]-Peptides

Oct 2005

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2005oleb...35..447o&link_type=abstract

Origins of Life and Evolution of Biospheres, Volume 35, Issue 5, pp.447-460

Computer Science

Origin Of Life, [Gadv]-Protein World Hypothesis, Pseudo-Replication Of [Gadv]-Proteins, Prebiotic Synthesis, Chemical Evolution, Peptide Catalyst, Primitive Enzyme

Scientific paper

We have previously postulated a novel hypothesis for the origin of life, assuming that life on the earth originated from “[GADV]-protein world”, not from the “RNA world” (see Ikehara's review, 2002). The [GADV]-protein world is constituted from peptides and proteins with random sequences of four amino acids (glycine [G], alanine [A], aspartic acid [D] and valine [V]), which accumulated by pseudo-replication of the [GADV]-proteins. To obtain evidence for the hypothesis, we produced [GADV]-peptides by repeated heat-drying of the amino acids for 30 cycles ([GADV]-P30) and examined whether the peptides have some catalytic activities or not. From the results, it was found that the [GADV]-P30 can hydrolyze several kinds of chemical bonds in molecules, such as umbelliferyl-β-D-galactoside, glycine-p-nitroanilide and bovine serum albumin. This suggests that [GADV]-P30 could play an important role in the accumulation of [GADV]-proteins through pseudo-replication, leading to the emergence of life. We further show that [GADV]-octapaptides with random sequences, but containing no cyclic compounds as diketepiperazines, have catalytic activity, hydrolyzing peptide bonds in a natural protein, bovine serum albumin. The catalytic activity of the octapeptides was much higher than the [GADV]-P30 produced through repeated heat-drying treatments. These results also support the [GADV]-protein-world hypothesis of the origin of life (see Ikehara's review, 2002). Possible steps for the emergence of life on the primitive earth are presented.

Affiliated with

Also associated with

No associations

Rating

Catalytic Activities Of [GADV]-Peptides does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Catalytic Activities Of [GADV]-Peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Catalytic Activities Of [GADV]-Peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-1656682