Can persistent Epstein-Barr virus infection induce Chronic Fatigue Syndrome as a Pavlov feature of the immune response?

Details Can persistent Epstein-Barr virus infection induce Chronic Fatigue Syndrome as a Pavlov feature of the immune response? Can persistent Epstein-Barr virus infection induce Chronic Fatigue Syndrome as a Pavlov feature of the immune response?

2011-02-04

arxiv.org/abs/1102.0933v1

Biology

Quantitative Biology

Cell Behavior

24 pages, 9 figures

Scientific paper

Chronic Fatigue Syndrome is a protracted illness condition (lasting even years) appearing with strong flu symptoms and with complex, systemic, defaiances by the immune system. Here we study the most widely accepted picture for its genesis, namely a persistent acute mononucleosis infection, by means of non-equilibrium statistical mechanics techniques and we show how this may drive the immune system toward an out-of-equilibrium metastable state (with long life-time) displaying chronic activation of both humoral and cellular responses: a scenario with full inflammation without a direct "causes-effect" reason. By exploiting a bridge with the neuronal scenario, we mirror killer lymphocytes $T_K$ and $B$-cells to neurons and helper lymphocytes $T_{H_1},T_{H_2}$ to synapses, hence showing that -under minimal physical assumptions- the immune system may experience the Pavlov conditional reflex phenomenon such that if the exposition to a stimulus (EBV antigens) is too long, strong internal correlations among $B,T_K,T_H$ may develop ultimately resulting in a persistent activation even though the stimulus itself is removed: Interestingly we found in literature several experimental findings which corroborate our outcomes.

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