Biology – Quantitative Biology – Neurons and Cognition
Scientific paper
2006-09-20
Journal of Neurophysiology, 97: 2544--2552 (2007)
Biology
Quantitative Biology
Neurons and Cognition
10 pages, 8 figures; final version published in the Journal of Neurophysiology
Scientific paper
The optimal patterns of synaptic conductances for spike generation in central neurons is a subject of considerable interest. Ideally, such conductance time courses should be extracted from membrane potential (Vm) activity, but this is difficult because the nonlinear contribution of conductances to the Vm renders their estimation from the membrane equation extremely sensitive. We outline here a solution to this problem based on a discretization of the time axis. This procedure can extract the time course of excitatory and inhibitory conductances solely from the analysis of Vm activity. We test this method by calculating spike-triggered averages of synaptic conductances using numerical simulations of the integrate-and-fire model subject to colored conductance noise. The procedure was also tested successfully in biological cortical neurons using conductance noise injected with dynamic-clamp. This method should allow the extraction of synaptic conductances from Vm recordings in vivo.
Bal Thierry
Destexhe Alain
Piwkowska Zuzanna
Pospischil Martin
Rudolph Michelle
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