Calcium signaling in UV-induced damage

Details Calcium signaling in UV-induced damage Calcium signaling in UV-induced damage

May 2007

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2007spie.6534e..86s&link_type=abstract

Fifth International Conference on Photonics and Imaging in Biology and Medicine. Edited by Luo, Qingming; Wang, Lihong V.; Tuch

Biology

Scientific paper

Hepa1-6 cells were irradiated with UV and incubated for varying periods of time. [Ca2+]i (intracellular calcium concentration) of UV-irradiated cell was measured by ratio fluorescence imaging system. The comet assay was used to determine DNA damage. During the UVB-irradiation, [Ca2+]i had an ascending tendency from 0.88 J/m2 to 92.4J/m2. Comet assay instant test indicated that when the irradiation dosage was above 0.88J/m2, DNA damage was observed. Even after approximate 2 h of incubation, DNA damage was still not detected by 0.88J/m2 of UVB irradiation. During UVA-irradiation, the elevation of [Ca2+]i was not dose-dependent in a range of 1200 J/m2-6000J/m2 and DNA damage was not observed by comet assay. These results suggested that several intracellular UV receptors might induce [Ca2+]i rising by absorption of the UV energy. Just [Ca2+]i rising can't induce DNA damage certainly, it is very likely that the breakdown of calcium steady state induces DNA damage.u

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