Brownian modulated optical nanoprobes

Details Brownian modulated optical nanoprobes Brownian modulated optical nanoprobes

Jan 2004

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2004apphl..84..154b&link_type=abstract

Applied Physics Letters, Volume 84, Issue 1, id. 154 (2004).

Astronomy and Astrophysics

Astronomy

3

Measurements Common To Several Branches Of Physics And Astronomy, Viscosity Measurements, Molecular Dynamics, Brownian Dynamics

Scientific paper

Brownian modulated optical nanoprobes (Brownian MOONs) are fluorescent micro- and nanoparticles that resemble moons: one hemisphere emits a bright fluorescent signal, while an opaque metal darkens the other hemisphere. Brownian motion causes the particles to tumble and blink erratically as they rotate literally through the phases of the moon. The fluctuating probe signals are separated from optical and electronic backgrounds using principal components analysis or images analysis. Brownian MOONs enable microrheological measurements on size scales and timescales that are difficult to study with other methods. Local chemical concentrations can be measured simultaneously, using spectral characteristics of indicator dyes embedded within the MOONs.

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